Relationships between free leptin and insulin resistance in women with polycystic ovary syndrome
نویسنده
چکیده
Background: Leptin is an adipokine that circulates in a free form and bound to a soluble leptin receptor. Patients with polycystic ovary syndrome have increased insulin resistance and high incidence of obesity. Objective: This study was carried out to evaluate levels of leptin and free leptin in women with polycystic ovarian syndrome (PCOS) and note any relationships with insulin resistance and adiposity. Materials and Methods: We assessed the correlation of metabolic parameters with the levels of free leptin and it’s bound form in 27 PCOS women (aged 26±5.6 years) and 27 healthy women with normal menstrual cycle as controls (aged 25 ±4 years).Total leptin and insulin levels were measured using ELISA. Free leptin form was purified by Gel filtration chromatography and their collected fractions were measured by a sensitive ELISA-Kit. Insulin resistance was calculated by homeostasis model assessment (HOMA). Results: In PCOS patients and control group a correlation between leptin and body mass index (BMI) was found. A significant difference was found between leptin and free leptin levels in PCOS subjects and controls (p<0.05). Significant correlations were found between free and total leptin with insulin resistant in PCOS subjects (r=0.78 p=0.00, r=0.84 p=0.003) and control groups respectively (r=0.86 p=0.00, r=0.69 p=0.00). Conclusion: Total and free leptin forms are correlated significantly with BMI in patients with PCOS and in controls. Total and free leptin forms showed significant correlations with insulin resistance but no significant difference was seen in the two groups investigated.
منابع مشابه
Leptin, Ghrelin, Adiponectin, Homocysteine and Insulin Resistance Related to Polycystic Ovary Syndrome
The relationship between leptin, adiponectin, ghrelin, homocysteine, insulin resistance and other biochemical factors in women with polycystic ovary syndrome (PCOS) is controversial. We review how the expanded role of these factors in reproduction might impact our understanding of PCOS. For purposes of our review, we accessed the PUBMED database during the past 10 years. Our review confirms tha...
متن کاملAssociation of Low Zinc Concentration and Hyperleptinemia with Overweight and Insulin Resistance in Polycystic Ovary Syndrome Women
Background and Objective: It has been reported that low concentration of zinc in serum is associated with insulin resistance (IR), also appears to be a relationship between insulin and leptin. In this study the possibility of increased leptin concentration and zinc deficiency was evaluated; in the following, their relationship with overweight and IR was investigated in women with polycystic ova...
متن کاملSerum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric,Metabolic, and Endocrine Parameters
متن کامل
غلظت سرمی روی (Zn) و ارتباط آن با سطح انسولین سرم در زنان مبتلا به سندرم تخمدان پلی کیستیک
Background & objective: Polycystic ovary syndrome is the most common endocrine disorder and main cause of infertility due to anovulation in reproductive aged women.With regard to the important role of insulin resistance and hyperinsulinemia in the pathophysiology of this syndrome and the role of zinc in structure and function of insulin hormone, as zinc dishomeostasis has adverse effect on the ...
متن کاملMetabolic and Endocrine Characteristics of Indian Women with Polycystic Ovary Syndrome
Objective Polycystic ovary syndrome (PCOS) is one of the most common endocrinological disorders among women of reproductive age and the leading cause of female infertility. This study intends to evaluate the lipid profile, hormonal levels [free T3 (fT3), free T4 (fT4), thyroid stimulating hormone (TSH), insulin, luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin] in PCO...
متن کامل